Mammalian nucleotide excision repair and syndromes
نویسندگان
چکیده
منابع مشابه
Mammalian nucleotide excision repair and syndromes.
Mammalian nucleotide excision repair and syndromes W. Vermeulcn*, J. de Boer*, E. Citterio*, A. J. van Gool*, G. T. J. van der Horst*, N. G. J. Jaspers*, W. L. dc Laat*, A. M. Sijbers*, P. J. van der Spek*, K. Sugasawa*, G. Weeda*, G. S. Winkler*, D. Bootsma*, J.-M. Egly-land J. H. J. Hoeijmakers. *Department of Genetics, Medical Genetics Centre, Erasmus University, P.O. Box I 738, 3000DR Rotte...
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DNA damage is implicated in cancer and aging, and several DNA repair mechanisms exist that safeguard the genome from these deleterious consequences. Nucleotide excision repair (NER) removes a wide diversity of lesions, the main of which include UV-induced lesions, bulky chemical adducts and some forms of oxidative damage. The NER process involves the action of at least 30 proteins in a 'cut-and...
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INTRODUCTION THE DEVELOPMENT and maintenance of life has critically depended on the evolution of mechanisms that ensure genetic integrity and stability. DNA, the vital carrier of genetic information, is continually subjected to undesired chemical alterations. Numerous environmental or endogenous compounds and various types of radiation, such as X-rays and ultra-violet (UV) light, induce a wide ...
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Nucleotide excision repair is the principal way by which human cells remove UV damage from DNA. Human cell extracts were fractionated to locate active components, including xeroderma pigmentosum (XP) and ERCC factors. The incision reaction was then reconstituted with the purified proteins RPA, XPA, TFIIH (containing XPB and XPD), XPC, UV-DDB, XPG, partially purified ERCC1/XPF complex, and a fac...
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As a blueprint for genetic information, the structural and functional integrity of DNA must be maintained during cell division and gamete formation. However, this fundamental principle is threatened continuously by the vulnerability of DNA itself and/or by assaults from endogenously produced agents, such as reactive oxygen species and other metabolites, as well as various environmental agents i...
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ژورنال
عنوان ژورنال: Biochemical Society Transactions
سال: 1997
ISSN: 0300-5127,1470-8752
DOI: 10.1042/bst0250309